Journal of Mid-life Health Journal of Mid-life Health
Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission | Subscribe | Advertise Users Online: 403  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 


ORIGINAL ARTICLE
Year : 2013  |  Volume : 4  |  Issue : 3  |  Page : 160-166

Efficacy and tolerability of fixed dose combination of metoprolol and amlodipine in Indian patients with essential hypertension


1 Department of General Medicine, Osmania General Hospital and Medical College, Hyderabad, Andhra Pradesh, India
2 Department of Cardiology, Apollo Hospital, Chennai, Tamil Nadu, India
3 Department of General Medicine, Dr. BR Ambedkar Medical College, Bengaluru, Karnataka, India
4 Department of Neurology, St. Theresa's General Hospital, Hyderabad, Andhra Pradesh, India
5 Department of General Medicine, Kasturba Medical College, Mangalore, Karnataka, India
6 Global Medical Affairs, Dr. Reddy's Laboratories, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Latha Subramanya Moodahadu
G 5, Mount Meru Apartment, Road # 5, Avenue 7, Banjara Hills, Hyderabad - 500 034, Andhra Pradesh
India
Login to access the Email id

Source of Support: Study was sponsored by Dr. Reddy’s Laboratories Ltd. Hyderabad, India, Conflict of Interest: Nil for authors 1 to 5. These authors are the investigators who conducted the study. Dr. Latha Subramanya Moodahadu and Dr. Ashis Patnaik are the employees of the sponsor company and are stakeholders having financial stakes in Dr. Reddy’s Laboratories Ltd. by means of salary, company stocks or both. Dr. Naveen Kumar B R was a former employee of Dr. Reddy’s Laboratories Ltd. and is presently not having any stakes in Dr. Reddy’s Laboratories Ltd.


DOI: 10.4103/0976-7800.119000

Rights and Permissions

Background: This open-labeled, post-marketing study was conducted to assess the efficacy and tolerability of fixed dose combination of amlodipine and metoprolol extended release capsules in mild to moderate hypertension in adult Indian patients. Materials and Methods: Of 101 enrolled patients, 64 drug naοve patients were treated with regimen A (amlodipine 5 mg + metoprolol 25 mg) and those with prior history of hypertension ( n = 37) were treated with regimen B (amlodipine 5 mg + metoprolol 50 mg) for 8 weeks. Treatment response was assessed at week 4 and 8. Dose up titration to regimen B was carried out for those who failed to achieve the target blood pressure (BP) at week 4 in regimen A and additional antihypertensives were added to those in regimen B. Safety laboratory tests were performed at baseline and end of study. Results: Mean age (±SD) of patients was 53.36 (±11.26) years and body weight (±SD) 63.40 (10.03) kg. Ninety five patients (94.06%) were only hypertensive and 6 (5.94%) had hypertension with history of coronary artery disease; mean duration (±SD) of hypertension was 42.50 (48.07) months. At baseline, patients had a mean (±SD) systolic blood pressure (SBP) and diastolic blood pressure (DBP) of 154.98 (±7.76) mmHg and 95.55 (±5.70) mmHg respectively. There was a statistically significant ( P < 0.001) reduction of 12.16% and 14.69% in SBP, 11.49% and 14.65% in DBP at week 4 and week 8 respectively, compared to baseline. Normalization of overall BP was achieved in 49.49% and 70.71% patients at week 4 and 8, respectively. Peripheral edema was reported in 2.97% (3/101) patients. Conclusion: This combination was safe, efficacious, and well-tolerated in study population.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4575    
    Printed112    
    Emailed1    
    PDF Downloaded549    
    Comments [Add]    

Recommend this journal