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 Table of Contents 
CASE REPORT
Year : 2014  |  Volume : 5  |  Issue : 4  |  Page : 192-194  

Sarcoma-like mural nodule in a borderline mucinous tumor of the ovary: A rare entity


1 Department of Pathology, DESUN (NEON) Reference Lab, Kolkata, West Bengal, India
2 Department of Pathology, Murshidabad Medical College and Hospital, Berhampore, Murshidabad, West Bengal, India
3 Department of Pathology, North Bengal Medical College, Sushrutanagar, Darjeeling, West Bengal, India

Date of Web Publication21-Nov-2014

Correspondence Address:
Kaushik Saha
42/9/2, Sashi Bhusan Neogi Garden Lane, Baranagar, Kolkata - 700 036, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-7800.145168

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   Abstract 

Sarcoma-like mural nodule (SLMN) is a very uncommon and misleading benign entity which may be associated with benign, borderline or malignant mucinous neoplasm of the ovary. It should be distinguished from other malignant mural nodules with sarcoma, carcinosarcoma or anaplastic carcinoma for proper management. We report a rare case of SLMN in a borderline mucinous tumor of the ovary in a 30-year-old lady. In spite of having confusing histopathological features the final diagnosis was made depending on the younger age of the patient, well circumscription of the nodule, absence of vascular invasion and immunohistochemical profile.

Keywords: Mural nodule, mucinous, ovary, sarcoma-like


How to cite this article:
Ghosh P, Saha K, Bhowmik S. Sarcoma-like mural nodule in a borderline mucinous tumor of the ovary: A rare entity. J Mid-life Health 2014;5:192-4

How to cite this URL:
Ghosh P, Saha K, Bhowmik S. Sarcoma-like mural nodule in a borderline mucinous tumor of the ovary: A rare entity. J Mid-life Health [serial online] 2014 [cited 2021 Dec 3];5:192-4. Available from: https://www.jmidlifehealth.org/text.asp?2014/5/4/192/145168


   Introduction Top


Mucinous cystic tumors of the ovary rarely contain one or more solid mural nodules in which the histological features differ markedly from the background of benign, borderline or malignant mucinous neoplasms. [1] Four varieties of mural nodules have been described, including true sarcomas, sarcoma-like mural nodules (SLMN), foci of anaplastic carcinoma and mixed type. [2] SLMN stend to occur in younger women and are characterized by smaller size, sharp demarcation, a heterogeneous cell population, and no serious impact on the prognosis. [3] It should be differentiated from true sarcomatous mural nodules and foci of anaplastic carcinoma with areas of sarcomatoid differentiation since both of these lesions carry a graver prognosis. [4] We report a very rare case of SLMN in a borderline mucinous tumor of the ovary.


   Case report Top


A 30-year-old unmarried female patient presented with progressive abdominal enlargement for last 7 months. She also complained of mild lower abdominal pain and discomfort for last 2 and half months. A cystic swelling of about 18-20 weeks size reaching just below the level of umbilicus was felt on physical examination. Her menstrual cycle was normal. Ultrasonography revealed a left ovarian cystic space-occupying lesion(SOL) of 12 cm × 9.6-cm size with internal echogenicity and septations. Uterus was normal in size and right adnexa were unremarkable. Her routine laboratory tests were otherwise normal. Left ovarian cystectomy was performed. Grossly the cystic ovarian mass [Figure 1]a measured 13.8 cm × 12 cm × 8 cm. The outer surface was smooth and grayish whitewith wide areas of congestion. The cut section revealed multilocularcyst containing reddish-brown thick mucoid fluid. An elevated firm,well-definednodular area measuring 4.8 cm × 3.6 cm × 2.5 cm was noticed on the inner surface of the largest locule. Microscopic examination displayed the histopathological features of a borderline mucinous tumor showing complex cribriform architecture with mild to moderate cellular atypia along with an adjacent circumscribed nodular area [Figure 1]b and d. However, no recognizable glandular structures infiltrating into the deeper part of the nodule were identified. The nodular area was predominantly composed of pleomorphic spindle cells with hyperchromatic nuclei and occasional prominent nucleoli arranged in a vaguely fascicular pattern. The pleomorphic cells focally demonstrated smooth muscle and rhabdomyoblastic differentiation [Figure 2]a and b. Frequent mitotic figures including atypical forms admixed with histiocytes and inflammatory cells especially eosinophils were noticed. Conspicuous areas of coagulative necrosis [Figure 2]c and hemorrhage were also observed. Immunohistochemistry for cytokeratin was focally positive and vimentin was diffusely positive in the pleomorphic spindle cells of the nodule. The atypical mucinous glands displayed strong cytokeratin positivity [Figure 2]d. Overall, the histopathogical features of the nodule closely mimicked that of a sarcoma except the presence of circumscription and absence of vascular invasion. True sarcoma, atypical inflammatory myofibroblastic tumor, carcinosarcoma were considered as differential diagnoses. However, considering the circumscription of the nodule in macroscopy as well as in microscopy along with corroborative histopathological and immunohistochemical findings, the diagnosis of a borderline mucinous tumor with SLMN was made.
Figure 1: (a) Mucinous cystic neoplasm of ovary with mural nodule (b) A well-circumscribed SLMN alongwith borderline mucinous tumor (H and E, ×100) (c) A cellular well-demarcated nodular area of SLMN (H and E, ×100) (d) Complex atypical cribriform glands of borderline mucinous neoplasm (H and E, ×400)

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Figure 2: (a) Photomicrograph showing prominent mitotic figures and smooth muscle differentiation in SLMN (H and E, ×400) (b) Rhabdomyoblastic differentiation in SLMN (H and E, ×400) (c) Photomicrograph showing coagulative necrosis in SLMN (H and E, ×400) (d) Atypical mucinous glands showing strong cytokeratin positivity and spindle cells of the nodule in the background displaying focal and weak cytokeratin positivity (H and E, ×100)

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   Discussion Top


In 1979, Prat and Scully [5] reported 14 cases of SLMNs, seven of them from the previous literature, and pointed outtheir favorable clinical behavior. They described three types of morphology in SLMNs namely pleomorphic and epulis type, pleomorphic and spindle cell type and giant cell-histiocytic type.Sarcomatous nodules can exhibit a variety of patterns, including fibrosarcoma, rhabdomyosarcoma, and undifferentiated sarcoma. Mixed nodules may feature carcinosarcoma or a mixed anaplastic carcinoma and sarcoma-like nodule. [2] The present case displayed the morphology similar to the pleomorphic and spindle cell type with areas of smooth muscle and rhabdomyoblastic differentiation.

In contrast to SLMNs,the sarcomatous nodules and foci of anaplastic carcinoma which can also present as mural nodule, tend to occur in older patients and are characterized by larger size, poor circumscription, a monotonous spindle cell population in the former, evidence of carcinomatous differentiation in the latter, and aggressive behavior. [3] Anaplastic carcinomatous nodules generally have spindled and rhabdoid cells with unequivocal cytologic features of a high-grade malignancy, and are associated with intraepithelial or invasive mucinous carcinoma in 72% of cases. [6] Atypical inflammatory myofibroblastic tumors may resemble SLMNs possibly due toa florid reaction to intramural hemorrhage or spilling of mucinous material in cystic ovarian tumors. In contrast to SLMNs that occur in association with an epithelial tumor, inflammatory myofibroblastic tumors have a predilection for relatively younger patients, appear de novo, and are larger and less well circumscribed. [7] Although various hypotheses have been proposed to explain the histogenesis of the SLMNs, it probably represents a reactive and self-limited phenomenon within a neoplasia. SLMNs usually strongly express vimentinand focally or weakly express cytokeratin, similar to true sarcomas yet distinct from anaplastic carcinomas that usually have strong/diffuse cytokeratin expression. [8] Thus even immunohistochemistry failed to differentiate SLMN in our case from true sarcoma. Finally the age of the patient, well circumscription of the nodule and lack of vascular invasion were the only parameters that led us to the correct diagnosis. In the recent past, Agarwal et al. [9] and Chakrabarti et al. [10] from India reported the cases of SLMNs in benign mucinous tumor of ovary.

The outcome of mucinous tumors with SLMNs is the same as the corresponding category of mucinous tumors without the nodule. [1] But SLMNs should be regarded with caution as their histologic appearance is worrisome and clinical follow-up data are very limited. [3]

Hence, careful and meticulous examination of this rare lesion within a mucinous cystic tumor is essential for reassuring the patient of a favorable clinical outcome and for excluding the similar looking aggressive lesions having poorer outcome.

 
   References Top

1.Lee KR, Tavassoli FA, Prat J, Dietel M, Gersell DJ, Karseladze AI, et al. Surface epithelial-stromal tumours. In: Tavassoli FA, Devilee P, editors. World Health Organization classification of tumours: Pathology and genetics of tumours of the breast and female genital organs. Lyon, France: IARC Press; 2003. p. 117-45.  Back to cited text no. 1
    
2.Nucci MR, Crum CP, Lee KR. The pathology of pelvic-ovarian epithelial (epithelial-stromal) tumors. In: Crum CP, Nucci MR, Lee KR, editors. Diagnostic gynecologic and obstetric pathology. 2nd ed. Philadelphia: Elsevier, Saunders; 2011. p. 818-95.  Back to cited text no. 2
    
3.Seidman JD, Cho KR, Ronnett BM, Kurman RJ. Surface epithelial tumors of the ovary. In: Kurman RJ, Ellenson LH, Ronnett BM, editors. Blaustein's Pathology of the Female Genital Tract. 6th ed. New York: Springer; 2011 p. 679-784.  Back to cited text no. 3
    
4.Seidman JD, Yemelyanova A. Pathology of mucinous tumors. In: Soslow RA, Tornos C, editors. Diagnostic Pathology of Ovarian Tumors. New York: Springer; 2011. p. 105-18.  Back to cited text no. 4
    
5.Prat J, Scully RE. Ovarian mucinous tumors with sarcoma-like mural nodules: A report of seven cases. Cancer 1979;44:1332-44.  Back to cited text no. 5
    
6.Provenza C, Young RH, Prat J. Anaplastic carcinoma in mucinous ovarian tumors: A clinicopathologic study of 34 cases emphasizing the crucial impact of stage on prognosis, their histologic spectrum, and overlap with sarcomalike mural nodules. Am J Surg Pathol 2008;32:383-9.  Back to cited text no. 6
    
7.Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859-72.  Back to cited text no. 7
    
8.Bagué S, Rodríguez IM, Prat J. Sarcoma-like mural nodules in mucinous cystic tumors of the ovary revisited: A clinicopathologic analysis of 10 additional cases. Am J Surg Pathol 2002;26:1467-76.  Back to cited text no. 8
    
9.Agarwal K, Meenakshi, Agarwal C, Jain K. Sarcoma-like mural nodule in an ovarian mucinous cystadenoma: A case report. Indian J Pathol Microbiol 2004;47:226-8.  Back to cited text no. 9
    
10.Chakrabarti S, Konar A, Biswas S, Das S. Sarcoma-like mural nodules in ovarian mucinous cystadenomas: A report of two cases. Indian J Med Sci 2005;59:499-502.  Back to cited text no. 10
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