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ORIGINAL ARTICLE
Year : 2020  |  Volume : 11  |  Issue : 4  |  Page : 236-239

A study of matrix metalloproteinase-2 and interleukin-18 in preinvasive and invasive lesions of cancer cervix


1 Department of Obstetrics and Gynaecology, KGMU, Lucknow, Uttar Pradesh, India
2 Department of Gynaecological Oncology, Super Speciality Cancer Institute & Hospital, Lucknow, Uttar Pradesh, India
3 Department of Pharmacology and Therapeutics, KGMU, Lucknow, Uttar Pradesh, India

Correspondence Address:
Uma Singh
Department Obstetrics and Gynaecology, (Queen Mary Hospital), Gynae Office KGMU, S1, Subhash Marg, Raja Bazar, Chowk, Lucknow - 226 003, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmh.JMH_87_19

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Introduction: Human Papilloma-Virus infection is the major event for cervical carcinogenesis, whereas host physiological changes may confer individual susceptibility and prognosis. So here, we aimed to compare serum levels of matrix metalloproteinase-2 (MMP-2) and interleukin-18 (IL-18) between cervical cancer patients and healthy controls. Materials and Methods: In the present study, we enrolled 168 subjects (10 CIN I, 10 CIN II, 10 CIN III, and 54 invasive cervical cancers with 84 age-matched healthy controls). Serum levels were estimated by enzyme-linked immunosorbent assay. Results and Discussion: The levels of serum MMP-2 showed a characteristic pattern of increasing trend with statistically significant P value on comparing pre-invasive lesions and cervical cancer versus healthy controls. However, IL-18 levels showed a decreasing trend in serum levels of controls versus cases with a statistically significant P value (P < 0.05). Conclusion: MMP-2 accentuates tissue damage and controls many interleukins secretion, which leads invasion and malignancy. Increased levels of MMP-2 and decreased circulating levels of IL-18 were found in cases. Hence, we raise an issue to study MMP-2 and IL-18 further for their diagnostic and prognostic marker role.


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