Journal of Mid-life Health Journal of Mid-life Health
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Year : 2022  |  Volume : 13  |  Issue : 3  |  Page : 247-250

Leydig cell hyperplasia of ovary – An unusual finding in postneoadjuvant chemotherapy case of primary fallopian tube carcinoma

1 Department of Pathology and Lab Medicine, AIIMS, Jodhpur, Rajasthan, India
2 Department of Surgical Oncology, AIIMS, Jodhpur, Rajasthan, India

Correspondence Address:
Meenakshi Rao
Department of Pathology, AIIMS, Jodhpur, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmh.jmh_117_22

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A large number of high-grade serous ovarian carcinomas originate in the fallopian tubes. Neoadjuvant chemotherapy followed by surgery may lead to a number of chemotherapy-induced changes in the ovary, which may lead to an erroneous diagnosis. We present a rare case of a 55-year-old postmenopausal woman who was clinically diagnosed with carcinoma of the right ovary; on histopathologic evaluation after neoadjuvant chemotherapy, the primary site was found to be the right fallopian tube. The right ovary showed chemotherapy-related changes along with extensive Leydig cell hyperplasia. As the presence of Leydig cell hyperplasia in this setting is an unusual finding, it may pose a diagnostic dilemma for the pathologist; so an awareness of this entity is important to avoid misdiagnosis.

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