 |
January-June 2010 Volume 1 | Issue 1
Page Nos. 1-50
Online since Tuesday, August 3, 2010
Accessed 83,174 times.
PDF access policy Journal allows immediate open access to content in HTML + PDF
EPub access policy Full text in EPub is free except for the current issue. Access to the latest issue is reserved only for the paid subscribers.
|
| |
|
Show all abstracts Show selected abstracts Add to my list |
|
EDITORIALS |
|
|
|
Midlife health: A mission |
p. 1 |
Sunila Khandelwal DOI:10.4103/0976-7800.66982 PMID:21799628 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
"Brave old" motherhood: Beyond biological boundaries |
p. 3 |
Rama Vaidya, Rashmi Shah DOI:10.4103/0976-7800.66984 PMID:21799629 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
REVIEW ARTICLES |
 |
|
|
|
Calcitonin gene-related peptide and menopause |
p. 5 |
Sudhaa Sharma, Annil Mahajan, Vishal R Tandon DOI:10.4103/0976-7800.66985 PMID:21799630The review summarizes recent findings with respect to pathophysiological role of calcitonin gene-related peptide (CGRP), in postmenopausal symptoms and diseases, which has opened horizons in understanding pathophysiology of menopause in a better way. Current evidences strongly propose a need to develop CGRP receptor antagonists, which may prove beneficial in many prevalent menopausal symptom/diseases such as vasomotor symptoms, cardiovascular risk, obesity, and major depressive disorder, in which CGRP levels are elevated. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (1) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Does ovarian autoimmunity play a role in the pathophysiology of premature ovarian insufficiency? |
p. 9 |
Vrinda Khole DOI:10.4103/0976-7800.66986 PMID:21799631Premature Ovarian Failure (POF) is an important cause of amenorrhoea and infertility. However some women may spontaneously ovulate and conceive. Primary ovarian insufficiency (POI) is thus the preferred term. POF / POI is multifactorial in etiology. Autoimmunity is an important mechanism for accelerated destruction of ovarian follicles. The present review focuses on the role of autoimmunity in the pathophysiology of POI. Antibodies to multiple ovarian antigens have been proposed as markers of ovarian autoimmunity. However, there has been lack of clinically proven sensitive and specific serum tests to confirm autoimmune involvement in POI. The review details recently developed specific test for antiovarian antibodies (AOA) that has enabeled identification of different molecular antigenic targets in the ovary. The application of this specific test for AOA has brought to light the need for screening for autoimmunity prior to patients undergoing IVF technique. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (3) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
ORIGINAL ARTICLES |
 |
|
|
|
Comparative evaluation of raloxifene versus estrogen: Progestin on symptomatology, endometrium, and lipid profile in postmenopausal women |
p. 14 |
Anuradha Dogiparthi, Neelam Aggarwal, Vanita Suri, Radhika Srinivasan, Sarla Malhotra DOI:10.4103/0976-7800.66988 PMID:21799632The objective of the study was to evaluate the effects of raloxifene and estrogen progesterone (E + P) combination on symptoms, endometrium, and lipid profile in postmenopausal women. Ninety healthy postmenopausal women were enrolled and allocated to three groups namely E + P, raloxifene, and controls. These groups were given 0.625 mg conjugated estrogen and 2.5 mg medroxyprogesterone, 60 mg raloxifene and no therapy, respectively. Symptomatology and lipid profile were evaluated at 3, 6, and 12 months. Endometrial thickness was evaluated at 6 and 12 months, and endometrial biopsy was repeated at 12 months. The demographic profile of the women in the three different groups was comparable. In addition, the symptomatology, lipid profile, mean endometrial thickness, and endometrial biopsy categorization were comparable. E + P and raloxifene were equally effective in improving the postmenopausal symptoms and lipid profile. E + P had stimulatory effect on the endometrium, whereas raloxifene was found to be neutral. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (1) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Bone mineral density in women above 40 years |
p. 19 |
Jyothi Unni, Ritu Garg, Rajeshwari Pawar DOI:10.4103/0976-7800.66989 PMID:21799633The prevalence of osteoporosis in India is high and osteoporotic fractures are thought to occur early in Indian women. The aim was to study the prevalence of osteopenia and osteoporosis in women aged above 40 years. Women aged above 40 years attending the out patient department of this hospital were offered bone densitometry. A significant positive correlation was found between age and time since menopause and bone mineral density (BMD). Differences in the prevalence of osteoporosis were noted on the basis of socioeconomic strata. There was no statistically significant difference observed in BMD for many of the other accepted risk factors such as age at menarche, lactation, and exercise. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (8) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Role of gray scale and color Doppler in differentiating benign from malignant ovarian masses |
p. 23 |
Dhwani Desai, VA Desai, RN Verma, A Shrivastava DOI:10.4103/0976-7800.66991 PMID:21799634Objectives: To evaluate prospectively the relative usefulness of color Doppler and gray scale sonography in differentiating benign from malignant ovarian masses and evaluation of scoring systems Sassone and Alcazar for differentiating benign from malignant ovarian masses.
Methods: Study was conducted during the period of Jan 2006 to Oct 2007 in department of obstetrics and gynaecology, New civil Hospital, Surat. The study was conducted mainly with the help of department of radio-diagnosis. The study include 100 patient clinically suspected to have ovarian neoplasm and referred to department of radio-diagnosis where evaluation with Ultrasonography and Doppler was done. The efficacy of scoring systems were evaluated by histopathological examination of mass or fine needle aspiration cytology or presence of malignant cells in ascetic fluid.
Results: Sassone's scoring system was able to identify 72 out of 78 benign masses and 18 out of 22 malignant masses.where as Alcazar system with use of colour Doppler was able to identify 75 out of 78 benign and 21 out of 22 malignant ovarian masses. Sensitivity and specificity of sassone is 81.8%,92.3% respectively, where as that of Alcazar is 95.5%, 96.2% respectively.
Conclusion: Using both gray scale and colour Doppler in differentiating benign from malignant ovariam masses is giving results with more accuracy and Alcazar system is better performing than sassone's scoring systems. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (3) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Prevalence of cardiovascular risk factors in postmenopausal women: A rural study |
p. 26 |
Vishal R Tandon, Annil Mahajan, Sudhaa Sharma, Anil Sharma DOI:10.4103/0976-7800.66993 PMID:21799635Aim: The present observational, cross-sectional prospective study was conducted during the period of 1 year in one of the rural health centers to study prevalence of conventional cardiovascular disease risk factors (CVRFs) in postmenopausal women.
Materials and Methods: Five hundred consecutive postmenopausal women were screened for detailed information regarding common menopausal symptoms, the presence or absence of conventional CVRFs. Physical activity was measured, and dietary lifestyle was also assessed. Use of hormone replacement therapy (HRT) and other drugs were also noted. Knowledge regarding their menopause was also evaluated.
Results: Mean age at menopause was 49.35 years, Mean number of menopausal symptoms was 6.70 ± 5.76, and mean duration since menopause was (MDSM = 4.70 years)). Fatigue, lack of energy (70%), cold hand and feet, rheumatology-related symptoms (60%) cold sweats, weight gain, irritability, and nervousness (50%), palpitation of heart, excitable/anxiety (30%) each were common complaints. Hypertension was diagnosed or a person was a known hypertensive (56%). Diabetes was diagnosed or a person was known diabetic in 21%, and BMI was found to be 25 kg/m 2 in 78%. Truncal obesity with waist-hip ratio >0.8 in 68% females, whereas abdominal obesity with waist size >88 cm was in 60% women. Dyslipidemia was seen in 39%. It was defined by the presence of high TC (=200 mg/dL) in 30%, high LDL-c (=130 mg/dL) in 27%, low HDLc (<40 mg/dL) in 21% or high TG (=150 mg/dL) in 31%. Metabolic syndrome was present in 13% of cases. CRP was found positive in 12 out of 39 total evaluated women, and serum uric acid was found >6.5 mg/dL in 4%. Smoking (0.5%), alcohol (0%,), tobacco chewing (4%), and family history of premature heart disease (9%) were recorded. Lifestyle was active in 35%, hectic in 10%, and sedentary in 55% of postmenopausal women (PMWs). Only 5% of women were receiving HRT, 0.5% isoflavone-containing phytoestrogens, 0.4% tibolone, 24% anti-HT, 9% anti-diabetic, 8% lipid-lowering drugs, and only three patients were on anti-obesity along with dietary and lifestyle management. Out of 68 patients, who were advised for electrocardiography (ECG), 23 were found positive for ischemic changes on ECG and out of 12 women advised for treadmill test (TMT), only four were found positive for ischemic heart disease (IHD). Risk factor count of more than four was found in 11%. Over all 96% of women were affected by menopause or related problems. Only 9% were aware about their menopause, 3% for importance of lifestyle modification, weight and dietary management programs to ameliorate menopause or menopause-compounded CVRFs.
Conclusion: This study showed alarmingly high prevalence of most of the conventional CVRFs, especially diabetes, hypertension, dyslipidemia, obesity, and other risk factors in postmenopausal women from rural areas. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (10) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Prevalence of premenstrual symptoms: Preliminary analysis and brief review of management strategies |
p. 30 |
JV Joshi, SN Pandey, P Galvankar, JA Gogate DOI:10.4103/0976-7800.66995 PMID:21799636Objective: To determine the prevalence of premenstrual cyclic symptoms in perimenopausal age.
Subjects and Methods: Women attending Bhavan's SPARC Maitreyi's Health Care Programme (HCP) for women around 40 years of age were included in the study. Last 200 women who attended from April 2002 to October 2004 are included for analysis. Out of these 107 qualified for final analysis as others were post hysterectomy or post menopausal. Thirty five symptoms listed under premenstrual tension syndrome were analysed.
Results: Forty one women (38.3%) had 3 or more symptoms whilst 15 (14.0%) had 5 or more cyclic symptoms. Five women (4.7%) reported that the symptoms were severe. Eleven women had seeked treatment for premenstrual tension syndrome (PMTS). The commonest symptom was mastalgia or heaviness of breasts. Next was whilst also was reported by several women. Women reported anger attacks and reported depression.
Conclusion: PMTS was common between 36 and 55 years. About half of them have experienced 3 more symptoms and 1 in 20 may require treatment. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (4) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
VIEW POINTS |
 |
|
|
|
Mid-career blues in healthcare workers: A physiological approach in ethical management |
p. 35 |
Amrith Pakkala DOI:10.4103/0976-7800.66994 PMID:21799637 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
Grandmother pregnancies: A medical hara-kiri? |
p. 38 |
Parul Kotdawala DOI:10.4103/0976-7800.66992 PMID:21799638 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
GUIDELINES |
 |
|
|
|
Guidelines and recommendations on hormone therapy in the menopause |
p. 41 |
Amos Pines DOI:10.4103/0976-7800.66990 PMID:21799639 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (1) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Third consensus meeting of Indian Menopause Society (2008): A summary |
p. 43 |
Jyothi Unni DOI:10.4103/0976-7800.66987 PMID:21799640 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (7) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
LETTER TO EDITOR |
 |
|
|
|
The Annual Conference of the British Menopause Society - June 2010 |
p. 48 |
Duru Shah DOI:10.4103/0976-7800.66983 PMID:21799641 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|